Efficient isolation of subacute sclerosing panencephalitis virus from patient brains by reference to magnetic resonance and computed tomographic images.

Isolation and characterization of a defective measles virus from brain biopsies of three patients in Iran with subacute sclerosing panencephalitis

Enrichment of measles virus-like RNA in the nucleocapsid fraction isolated from subacute sclerosing panencephalitis brains.

A procedure has been developed which facilitates the detection of measles virus RNA sequences in human brains. The procedure involves isolating subviral components (nucleocapsids) from brain tissues prior to RNA purification, followed by hybridization of these RNAs to cDNA synthesized from measles virus 50 S RNA template. Using these techniques we were able to obtain an RNA fraction which was m...

LETTERS TO THE EDITOR In vivo cerebral proton MRS in a case of subacute sclerosing panencephalitis Subacute sclerosing panencephalitis

Subacute sclerosing panencephalitis (SSPE) is a rare encephalopathy caused by persistent defective measles virus in the CNS. Brain lesions may involve all regions of the CNS. The pathophysiological events associated with the disease are characterised by a perivascular infiltration by monocytes and astrocytic proliferation, neuronal degeneration, and demyelination. The exploration of SSPE by bra...

Fulminant subacute sclerosing panencephalitis in an individual with a perinatally acquired human immunodeficiency virus infection.

BACKGROUND Case reports of subacute sclerosing panencephalitis (SSPE) in individuals with human immunodeficiency virus (HIV) infection are scarce, and the natural history is unclear. To our knowledge, a fulminant presentation has not yet been described. OBJECTIVE To describe a case of fulminant SSPE in an individual with a perinatally acquired HIV infection. DESIGN Case report and literature re...

Subacute Sclerosing Panencephalitis, immunological findings in saliva and salivary glands